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For the past 50 years, Shiseido has been researching for the reasons behind sensitive skin problems.Seasonal changes | Dryness | Ultraviolet rays | Air pollution | Life rhythm disturbances
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Causes of Sensitive Skin

Under Shiseido, d program is developed to continuously tailor suitable skincare solutions to tackle these sensitive skin problems. While these solutions are important, d program also believes that there are underlying fundamental causes of sensitive skin.

Upon researching, Shiseido had focused its research on microbiomes that reside on our skin. Among these microbiomes, Shiseido specifically selected and focused deeper on “Beauty microbiome”, which was observed to help maintain skin health.

What is Beauty Microbiome?

There are 1000* types of microbiome on our skin. Among these, one representative Beauty microbiome, Staphylococcus epidermidis exists.

Beauty microbiome plays a key role in maintaining skin beauty and can vary in different types and numbers, depending on where they reside.

As each individual is unique, the profile of Beauty microbiome also differs, just like our fingerprints.

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Functions of Beauty Microbiome
1) They help build the natural moisturising function for the skin.

“Staphylococcus epidermidis”, which is the representative of Beauty microbiome, produces glycerin and fatty acids, which play active roles in the natural skincare function. Glycerin helps to keep skin moisturised while fatty acids help to maintain the skin pH level to balance skin microbiome. In other words, this helps to produce a natural moisturising layer on the skin. It also enhances skin resilience as it plays a key role to strengthen skin’s barrier function.

As each individual is unique, the profile of Beauty microbiome also differs, just like our fingerprints.

Maintain skin barrier function | Staphylococcus epidermidis | Sebum | Glycerin (keeps skin moisturized) | Perspiration | Fatty acids (keeps the skin weakly acidic, and balances skin microbiome)
2) They strengthen the barrier function.

Beauty microbiome have also been found to enhance the barrier function from two main approaches.

1. Physical barrier - Strengthening the 'tight junction' between epidermal keratinocytes to build a defense barrier wall with little gaps | Ohnemus et al.,  JID 128, 906-916 (2008) | 2. Biological barrier - Encourage the selective dominance over harmful microbiome such as Staphylococcus aureus and keeps the balance of skin microbiome. | Lai et al., JID 130, 2211-2221 (2010), Cogen et al., JID 130, 192-200 (2010) | External stimuli | Tight junction | Stratum
corneum  | Epidermis  | Basement membrane | Moisture
The Relationship Between
Beauty Microbiome and Sensitive Skin

Shiseido examined the skin microbiome on the skin of healthy Japanese women (ages 20-69).

When comparing between sensitive and normal skin, it has been discovered that the ratio of Staphylococcus epidermidis, a representative of beauty microbiome was lower for sensitive skin.

Nakako Shibagaki Photo
Nakako Shibagaki, Ph.D.
Researcher of Global Innovation Center,
Shiseido Co., Ltd.
New findings! Sensitive skin and Beauty microbiome

Does sensitive skin have a low ratio of Beauty microbiome?

Compared to normal skin, it was found that sensitive skin had fewer Beauty microbiome. This could indicate that skin may not be at its optimum condition.

Ratio of Staphylococcus  epidermidis (to Propionibacterium acnes) | Normal skin | Sensitive skin | Shiseido  survey conducted in December 2019

It became clear that it is important to increase Beauty microbiome in order to bring delicate skin closer to beautiful skin.

Further Discovery on
Beauty Microbiome and Sensitive Skin

Correlation between the amount of moisture and the ratio of Staphylococcus epidermidis in indigenous bacteria on the cheeks of 41 women in their 20s and 30s.

Skin Moisture

Correlation between the cheeks' reddishness and the ratio of Staphylococcus epidermidis in indigenous bacteria on the cheeks of 36 women in their 20s through early 40s.

Skin Reddishness

Shiseido research has revealed that skin with less proportion of Beauty microbiome has lower moisture retention and tendency of redness appearance. On the contrary, skin with a higher ratio of Beauty microbiome has better moisture retention and a healthy skin appearance.

In summary, the role of Beauty microbiome is very important for sensitive skin.

d program’s Lotion & Emulsion series contains
Yeast Extract Complex that increases Beauty microbiome

Sensitive skin requires Beauty microbiome. Inspired by this discovery, d program developed a new skincare series that is formulated with Yeast Extract Complex to increase Beauty microbiome, ideal for those with sensitive skin problems.

Five Different Programs For Different Skin Types
Balance CareFor Combination Skin

Rebalances skin hydration and oil production to prevent visible and clogged pores.

90%* of women agreed that this range reduced and minimised the appearance of pores in 14 days.

Balance Care Complex Formulation

Contains Balance Care Complex (a combination of Tranexamic Acid, Theanine and Glycerin) which

  • soothes and moisturises skin
  • balances oiliness and dryness
  • prevents clogged pores and sebum retention
  • prevents pore problems caused by excessive sebum secretion
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Acne CareFor Acne-Prone Skin

Helps treat and prevent new acne while reducing scarring without drying skin.

87%* of women agreed that this line relieved and reduced recurring acne in 14 days.

Acne Care Complex Formulation

Contains Acne Care Complex (a combination of Tranexamic Acid and Winter Begonia Extract) which

  • soothes and hydrates skin
  • controls sebum and prevents clogging of pores
  • improves acne skin conditions and prevents new outbreaks
  • prevents pigmentation of acne scars and skin inflammation
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Moist CareFor Dry & Rough Skin

Improves severe dryness and dehydration by providing ample moisturisation.

96%* of women agreed that this line improved severe dryness, dehydration and flaking in 14 days.

Moist Care Complex Formulation

Contains Moist Care Complex (a combination of Tranexamic Acid, Hyaluronic Acid, Vaseline, Mugwort Extract and Glycerin) which

  • soothes and moisturises skin
  • repairs and protects skin from dryness-related issues
  • relieves and prevents itching caused by dryness
  • promotes moisture retention and creates a barrier film to protect skin from external stimuli and excessive moisture loss
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Vital ActFor Mature & Ageing Skin

Protects skin against signs of ageing and visibly reduces appearance of lines and wrinkles.

92%* of women agreed that this line minimised visible ageing signs in 14 days.

Vital Act Complex Formulation

Contains Vital Act Complex (a combination of Tranexamic Acid, Extracts of Chestnut Rose Fruit, Onosis Spinosa Root, Starfruit Leaf, Yoshino Cherry Leaf and Glycerin) which

  • soothes and moisturises skin
  • refines skin texture by boosting collagen production
  • repairs and strengthens skin’s basement membrane, an important membrane that connects the epidermis and dermis, but weakens with age
  • creates NMFs that bolster moisture retention and firm skins
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Brightening ClearFor Dull & Irritated Skin

Hydrates and improves appearance of dark spots and skin dullness while reducing melanin production.

94%* of women agreed that this line brightened skin and improved the look of dark spots and skin dullness in 14 days.

Brightening Clear Complex Formulation

Contains Brightening Complex (a combination of m-Tranexamic Acid, Extracts of Hawthorn, Great Burnet Root, White Dead-Nettle, Trimethylglycine, Sodium Hyaluronate and Glycerin) which

  • soothes and moisturises skin
  • moisturises skin deeply and develops skin’s translucency and radiance
  • reduces melanin production to prevent dark spots, skin dullness and blemishes
  • improves skin’s complexion and reduces skin issues related to redness and dark spots
*Based on consumer research on 108 Asian females, Oct – Nov 2020
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